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Harmful algal blooms occur all around the world, threatening human health and destroying marine ecosystems.Alexandriurn tamarense is a globally distributed notorious toxic dinoflagellate, which responsible for most poisoning incidents by paralytic shellfish poison.The culture supematant of the marine algicidal bacterium BS02 showed high algicidal effects on A.tamarense ATGD98-006.In this study, we investigated the effect of the supernatant on A.tamarense at physiological and biochemical levels to elucidate the mechanism involved in BS02 inhibition of algal growth.