【摘 要】
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Estrogen receptors (ERs) are expressed in approximately 65% of human breast cancer and 50% of ovarian cancer.Accumulative data from clinical observations su
【机 构】
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Department of Pathology and Laboratory Medicine Medical University of South Carolina USA
【出 处】
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BIT Life Sciences' 1st Annual World Cancer Congess-2008(
论文部分内容阅读
Estrogen receptors (ERs) are expressed in approximately 65% of human breast cancer and 50% of ovarian cancer.Accumulative data from clinical observations suggest that some chemotherapeutic agents may be less effective in patients with ER positive (ER+) tumors than those with ER negative (ER) tumors.Paclitaxel is an active agent used in breast cancer chemotherapy.To investigate the possible influence of ER on the therapeutic efficacy of paclitaxel and its underlying mechanism, we established several isogenic ER+ cell lines by stable transfection of ER expression vectors into ER breast cancer BCap37 cells.
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