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Aim: To investigate the anti-arrhythmic mechanism of taurine magnesium coordination compound (TMCC) on abnormal inward rectifier potassium current (IK1) induced by hypoxia-reoxygenation in cardiomyocytes of rat.Methods: Enzymatic dissociation which through Langendorff retrograde aortic perfusionwas used to get single rat ventricular myocytes.