Objectives To determine whether polymorphisms in the LTA gene and IL-10 gene were associated with gastric cancer (GC) in a Chinese population.Methods 196 GC patients and 248 healthy individuals were enrolled in this case-control study.Results The LTA 252G was associated with an increased risk of GC, with an adjusted odds ratio of 1.74 (95%CI:1.12-2.69) for the LTA 252G heterozygotes and 2.42 (95% CI: 1.28-4.58) for the LTA 252G homozygotes as compared with noncarriers.In contrast, such association is not found in polymorphisms in IL-10.Furthermore, a potential interaction between LTA +252 G allele and IL-10-1082 G/A was associated with the occurrence of GC (adjusted OR: 1.91;95% CI: 1.01-3.64).Conclusions The LTA+252G allele is associated with increased risk for the presence of GC in the H.pylori positive subgroup.Potential interaction between IL-10 and LTA may contribute to the development of GC.