Idiopathic pulmonary fibrosis(IPF)is a progressive life-threatening disease that is characterized anatomically by scarring of the lungs and symptomatically by exertional dyspnea.Currently,there is no
Two epimers,(20S,24R)-epoxy dammarane-3β,12β,25-triol(3)and(20S,24S)-epoxy dammarane-3β,12β,25-triol(4)were prepared from 20(S)-protopanaxadiol,which were confirmed by ESI-MS,NMR,and X-ray single-crys
磷脂酰肌醇-3-激酶(PI3K)为一类脂激酶,参与调控细胞增殖、存活、凋亡、代谢等生物学过程。在多种人类肿瘤中,PI3K 信号通路由于多个关键组成蛋白存在异常改变而过度激活,使得PI3K 成为肿瘤治疗的重要靶标。
Reaction mechanisms of peroxynitrite with amino acids are the bases to explore the damage of protein induced by peroxynitrite.Here,by using stopped flow instrument,UV-visible spectra,fluorescence spec
腺点金丝桃为藤黄科金丝桃属植物,主要分布于我国新疆的天山、阿尔泰山、塔尔巴哈台山前山至中山地区[1],民间用作抗菌、消炎、止血生肌、抗抑郁等。现代药理实验实验证明间苯三酚类化合物是其活性成分[2-5],为了得到腺点金丝桃的活性成分,我们对腺点金丝桃地上部分的乙醇提取物进行了分离,并用各种光谱学方法(IR,UV,MS,1D-NMR,2D-NMR)和化学方法进行鉴定,共鉴定了8 个间苯三酚类化合物,其
Aim: Epithelial-mesenchymal transition(EMT)plays crucial roles during embryonic development and carcinoma progression,through downregulating epithelial markers and disassembling cell-cell adhesions,re