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选择60~70 岁老年人和18~25 岁青年人,应用3HTdR掺入法检测淋巴细胞转化能力和血清IL2 水平;用细胞毒活性检测法检测NK细胞活性。结果表明,老年人的上述3 种免疫指标明显低于青年人,说明老年人的细胞免疫功能低下。给老年人服用免疫调节剂4 周后再测定3种指标明显升高,与服免疫调节剂前相比差异显著(P< 0-01),并接近青年人水平。提示免疫调节剂能提高老年人的细胞免疫能力。
The 60- to 70-year-old and the 18-25-year-olds were selected. The 3H-TdR incorporation assay was used to detect lymphocyte transformation and serum IL 2 levels. The activity of NK cells was measured by cytotoxicity assay. The results showed that the above three immune indexes in the elderly were significantly lower than those in young people, indicating that the elderly had low cellular immune function. After 4 weeks of administration of immunomodulatory agents to the elderly, the three indicators were significantly increased, which was significantly different from that before the administration of immunomodulatory agents (P < 0-01), and was close to the level of young people. It is suggested that immunomodulators can improve the cellular immunity of the elderly.