Human Herpes virus type 8 or Kaposi Sarcoma associated Herpes Virus (HHV-8/KSHV), is the eighth member of human herpesvirus family.Many diseases are thought to be associated with HHV-8 infection.Kaposi sarcomas (KS), Primary Effusion Lymphoma (PEL) and Multicentric Castelmans Disease are the main clinical presentations that are associated with HHV-8 infection.They usually affect immunosuppressed patients such as HIV patients and organ transplant recipients.In all these clinical settings, HHV-8 is an important, but not sufficient to develop such a disease and there are many factors that contribute to HHV-8 disease development.