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Backgroud It has been reported that both gene ABCC 11 polymorphism and apolipoprotein D (ApoD), the odor precursor carrier, may play important roles on the formation of characteristic odor in axillary.But whether there is interaction between the two defined factors has yet been concealed.In the present study, we investigate the relationship between a single-nucleotide polymorphism (SNP) 538 G> A of ABCC 11 gene and the mRNA expression of ApoD in apocrine gland of the osmidrosis patients.