【摘 要】
：
Due to the insensitiveness of the available diagnostic markers such as serum creatinine or microalbuminuria determination, which would not screen early stag
【机 构】
：
Deparment of Physiology Faculty of Medicine Chulalongkorn University Thailand
论文部分内容阅读
Due to the insensitiveness of the available diagnostic markers such as serum creatinine or microalbuminuria determination, which would not screen early stage of diabetic ncphropathy (chronic kidney disease stages 1-2; creatinine clearance 60-119 ml/min/1.73m-2), treatment of diabetic nephropathy is usually initiated at late stage (chronic kidney disease stages 3-5; creatinine clearance under 60 ml/min/1.73m2).Such treatment fails to restore renal perfusion and function due to the defective mechanism of vascular repair namely vascular endothelial growth factor (VEGF), VEGF receptor1, VEGF receptor-2, angiopoietin-2, and impaired nitric oxide production.
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