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Cyanobacteria produce harmful algal blooms(HABs)and then cause water pollution worldwide and a hazard to animal and human health.Cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphosphatase(Cy-FBP/SBPase)is a special and important enzyme and is thought as a potential enzymatic target for screening of novel inhibitors that combat HABs.