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Ain Adult neurogenesis is the process of generating new neurons throughout life in the olfactory bulb and hippocampus of most mammalian species.Substantial studies has been made in deciphering alterations in adult neurogenesis are closely related to human disorders, including neurodegenerative disease, cerebrovascular disease and traumatic brain injury (TBI).The cellular and molecular mechanisms underlying adult neurogenesis in humans remain to be a mystery.A series of researches links neurogenesis to Nicotinamide phosphoribosyltransferase(NAMPT), a ratelimiting enzyme for mammalian NAD salvage synthesis.Although P7C3 compounds have neuroprotective efficiency by enhancing the activity of NAMPT, most of them were verified in the animal disease model.Fortunately, novel cell culture methods, such as patientsderived or genomeedited pluripotent stem cells (hESCs)and threedimensional (3D) organoid culture system, bring hope to drug testing and further develop specific medicine for neurodegenesisassociated diseases.