Traditional therapy aimed at changing tumor microenvironment makes efforts on reducing tumor vessel density to control its growth.However, starving therapy may be effective at early treatment but potentially contribute to tumor hypoxia, drug resistance and metastasi s.A new strategy by enhancing tumor angiogenesis in combination with effective chemotherapeutic drugs, has shown successful tumor growth and spread inhibition.To achieve in situ release of angiogenic and antitumor drugs in tumor, we designed a ratiometric polymeric system of TSP-TN hybrid micelles for co-delivering nitric oxide and paclitaxel.The hybrid micelles could accumulate in tumor via the long blood circulation and EPR effect,promote the drug penetration and retention in tumor by in situ angiogenesis and vessel dilation, and achieve the synergistic antitumor effect of nitric oxide and paclitaxel through different pathways.This study presents a stereo combinational therapy against tumor progression and shows a great potential in future cancer therapy.