【摘 要】
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Actin and Myosins,the molecular motors of the cell cytoplasm have been studied for many years.Hovever,it is still under debate whether there are molecular motor
【机 构】
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BiodynamicOpticalImagingCenter(BIOPIC),SchoolofLifeSciences,PekingUniversity,Beijing100871
【出 处】
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中国化学会第三届全国生物物理化学会议暨国际华人生物物理化学发展论坛
论文部分内容阅读
Actin and Myosins,the molecular motors of the cell cytoplasm have been studied for many years.Hovever,it is still under debate whether there are molecular motors within the nucleus,and if so,how they play their roles.It has been reported that nuclear motor complexes are involved in transcription,chromatin remodeling,and chromosomes reposition.Using cross-linking and LC/MS (liquid chromatography-mass spectrometry),we identified hundreds of proteins that interact specifically with cytoplasmic actin and nuclear actin,respectively.Moreover,we also discovered that some nuclear proteins,which interact with both nuclear actin and NMI (nuclear myosin I),were involved in a variety of nuclear processes,such as transcription,DNA replication,and DNA repair.These results provide us insight into how myosins and nuclear actin fulfill their motor functions in diverse nuclear processes.
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