Cordyceps militaris is a potential harbour of bio-metabolites for herbal drugs and evidences are available about its applications for revitalization of various systems of the body from the ancient time.Amongst all the species, the C.militaris is considered as an oldest source of some useful chemical constituents.Besides their popular applications for tonic medicine by the all stairs of the community, the constituents of C.militaris are now using extensively in the modem systems of medicines.The current survey records the mystery potentials of C.militaris are boosting up the present herbal treatments as well as gearing up the green pharmacy revolution in order to create a friendly environment with reasonable safety.Evidence showed that the active principles of C.militaris are beneficial to act as pro-sexual, anti-inflammatory, anti-oxidant/anti-aging, immunomodulatory, steroidogenic, hypoglacaemic, hypolipidaemic, anti-tumor/cancer, anti-proliferative, anti-metastatic, insecticidal, anti-fibrotic, anti-angiogenetic, anti-diabetic, anti-bacterial, anti-microbial, anti-fatigue, liver-protective, reno-protective, pneumo-protective, anti-viral, anti-HIV, anti-protozoal, anti-fungal, larvicidal, neuroprotective as well as antibacterial agents, let alone their other synergistic activities, which let it be marketable in almost all the countries of the world as over-the-counter medicine.The prospects for herbal biotechnology regarding drug discovery and the prevention of diseases using C.militaris delivering what it has promised are high, as the technology is now extremely powerful than before.This study highlights the importance of the fungus C.militaris for the prevention of some life-killing disease like cancer due to its novel clinical and pharmaceutical importance, also aiming to draw sufficient attention of the frontier research needs in this context as an herbal origin anti-cancer drug.