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OBJECTIVE: Internet gaming addiction (IGA),as a subtype of internet addiction disorder (IAD),is rapidly becoming a prevalent mental health concern around the world.The pathogenesis of IAD,however,remains unclear.This study investigated the brain functions in IGA patients with task-state fMRI.METHODS: 19 IGA and 19 matched healthy controls participated in this study.They all received the stimuli of internet video game play,while the 3.0 Tesla MRI was used to record the results of echo plannar imaging.RESULTS: The internet video game play markedly activated IGA group and control group.The actived brain regions of the controls included right superior frontal gyrus,right middle frontal,right inferior frontal gyrus,left insular lobe and right precuneus.IGA group showed actived brain regions that mainly distributed over right medial frontal gyrus,right middle frontal gyrus,superior frontal gyrus,bilateral superior temporal gyrus,left transverse temporal gyrus,right inferior parietal gyrus,right inferior parietal lobule,right precuneus,right posterior lobe.Compared with control group,IGA group showed increased activation in right superior parietal lobule,right insular lobe,right precuneus,right cingulated gyrus,right superior temporal gyrus,and left brainstem.There is a significantly difference in number of activated voxels in the two groups.An average of 1078 voxels was activated in IGA group while only 232 voxels in control group.CONCLUSIONS: Cue-induced internet video game play activates the vision,space,attention and execution centers composed of occipital temporal parietal and frontal gyrus.Abnormal brain function is noted in IGA subjects with hypofunction of the frontal cortex.IGA subjects show laterality activation of right cerebral hemisphere.