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肿瘤组织缺氧，这与癌症息息相关[1]。在低氧状态下的肿瘤中，生物还原性酶会过度表达(例如：偶氮还原酶，硝基还原酶，醌类酶)。基于此，我们利用类似喜树碱结构的抗癌药物作为荧光团，设计并合成了一个偶氮类低氧型的荧光探针[2]。
对低氧型偶氮类荧光探针的细胞成像和肿瘤检测研究
【摘 要】
：
肿瘤组织缺氧，这与癌症息息相关[1]。在低氧状态下的肿瘤中，生物还原性酶会过度表达(例如：偶氮还原酶，硝基还原酶，醌类酶)。基于此，我们利用类似喜树碱结构的抗癌药物作为荧光团，设计并合成了一个偶氮类低氧型的荧光探针[2]。
【机 构】
：
云南大学化学科学与工程学院.药学院 云南省昆明市五华区翠湖北路2号云南大学化学楼,650091
【出 处】
：
中国化学会第十届全国化学生物学学术会议
【发表日期】
：
2017年10期
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