【摘 要】
：
Metamorphic proteins can reversibly interconvert between different fold topologies under physiological condition.The transition of fold topology, e.g.protei
【机 构】
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NationalNMRCenterinBeijingPekingUniversity5YiheyuanRoadBeijing,China100871
【出 处】
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第四届吴宪吴瑞国际学术研讨会、第九届全国医学生物化学与分子生物学、第六届全国临床应用生物化学与分子生物学联合学术讨论会
论文部分内容阅读
Metamorphic proteins can reversibly interconvert between different fold topologies under physiological condition.The transition of fold topology, e.g.protein metamorphosis,normally involves changes in secondary structure elements, unpacking and repacking of protein hydrophobic core, and exposure of new surfaces.The C-terminal domain (Mpro-C) of SARS-CoV main protease adopts two different fold topologies, a monomer and a 3D domainswapped dimer which are relatively stable at room temperature.
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