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Objectives We had reported a missense mutation(C176W)in the M2-muscarinic acetylcholine receptor (CHRM2)gene associated with familial dilated cardiomyopathy.However,the exact molecular mechanisms by which the C176W mutation contributes to familial DCM was still unclear.Our aim was to identify differential proteins related to cadiac dysfunction activated via M2 muscarinic receptor with C176W mutation.